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2-OTBDMS-A Bz

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2-OTBDMS-A Bz Specification

Melting Point
160170C

Solubility
Soluble in DMSO, DMF; slightly soluble in water

HS Code
29349900

Grade
Research Grade

Properties
High purity, moisture sensitive, protected nucleotide for oligonucleotide synthesis

Poisonous
Non-poisonous

Taste
Not determined

Product Type
Nucleoside derivative

CAS No
123334-48-9

Molecular Formula
C23H34N5O5Si

Refractive Rate
Not determined

Shelf Life
2 years (when properly stored)

Density
Gram per cubic centimeter(g/cm3)

Smell
Odorless

Shape
Crystalline

Purity
>=97%

Usage
Suitable for automated DNA/RNA synthesizers

Application
Used in oligonucleotide and RNA synthesis

Physical Form
Powder

Appearance
White to off-white solid

Molecular Weight
487.63 g/mol

Ph Level
Neutral

Storage
Store at -20C, protected from moisture

Ingredients
2-O-(tert-Butyldimethylsilyl)adenosine, benzoyl protected

Structural Formula
(C23H34N5O5Si) structure

Stability
Stable under recommended storage, hydrolyzes in presence of moisture

Quality Control
HPLC, NMR confirmation

Synonyms
2-O-tert-Butyldimethylsilyl adenosine, benzoyl protected

Handling Precautions
Use gloves and eye protection, handle in argon or nitrogen atmosphere

Sensitive to
Moisture and light

Typical Package Size
100 mg, 250 mg, 1 g

Protective Groups
Bz at exocyclic amine, TBDMS at 2-OH

Transport Condition
Ambient or cold pack as per requirement

2-OTBDMS-A Bz Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
Western Europe, Australia, North America, Eastern Europe, Central America, Middle East, South America, Asia, Africa

Main Domestic Market
All India

About 2-OTBDMS-A Bz

2-OTBDMS-A Bz

CAS No : [104992-55-4]

M.Wt. 787.97

M.F. C44H49N5O7Si

Specification :

*Appearance: White to Off white powder,

*HPLC Purity: NLT 98%

*5'-ODMT-2'-OTBDMS Uridine (3'-Isomer): NMT 0.3%

*Residual Solvent: NMT 3.0%

*Moisture content by KF: NMT 1.0%

*1H NMR (Solvent : DMSO d6): Conforms with Structure

*LCMS: Corresponds to Mass

*APHA Test in 0.2M in DMSO: NMT 250

*Solubility: 0.2M in MDC

Key Features and Applications

2-OTBDMS-A Bz is specially formulated for use in oligonucleotide and RNA synthesis, compatible with automated DNA/RNA synthesizers. Its high purity (97%) and protective groups (Bz and TBDMS) enable precise and efficient nucleotide incorporation. This makes it an indispensable reagent for researchers requiring stringent quality and performance in molecular biology workflows.

Safe Handling and Storage Recommendations

For maximum stability and safety, 2-OTBDMS-A Bz must be handled with gloves and eye protection, in an inert gas atmosphere such as argon or nitrogen. The compound is highly sensitive to moisture and light; therefore, storage at -20C in a tightly sealed container is essential. Under these conditions, its shelf life extends up to 2 years.

FAQs of 2-OTBDMS-A Bz:

Q: How should 2-OTBDMS-A Bz be stored to maintain stability?

A: 2-OTBDMS-A Bz should be stored at -20C, protected from moisture and light, in a tightly sealed container. These precautions help preserve its stability and extend its shelf life up to two years.

Q: What is the recommended process for handling 2-OTBDMS-A Bz?

A: When handling 2-OTBDMS-A Bz, use gloves and eye protection, and perform operations under an argon or nitrogen atmosphere to avoid moisture exposure. This preserves its structural integrity and prevents hydrolysis.

Q: Where is 2-OTBDMS-A Bz commonly used?

A: This compound is primarily used in research laboratories for oligonucleotide and RNA synthesis, often in conjunction with automated DNA/RNA synthesizers for high-fidelity sequence assembly.

Q: What are the main benefits of using 2-OTBDMS-A Bz in nucleotide synthesis?

A: The main benefits include its high purity, specific protective groups that facilitate selective reactions, and compatibility with automated synthesis equipment, resulting in efficient and accurate nucleotide assembly.

Q: When is 2-OTBDMS-A Bz most effective for application in synthesis?

A: 2-OTBDMS-A Bz is most effective when used under dry conditions in controlled laboratory environments, particularly during the synthesis of modified oligonucleotides or RNA strands requiring precise protection protocols.

Q: What is the typical physical appearance and solubility of 2-OTBDMS-A Bz?

A: It appears as a white to off-white crystalline powder and is soluble in DMSO and DMF, with slight solubility in water, making it suitable for various laboratory procedures.

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