5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

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5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

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5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine Specification

Poisonous
Non-poisonous

Molecular Formula
C40H42N6O7

Melting Point
152-158C

Smell
Odorless

Properties
Protecting group for oligonucleotide synthesis; used in solid phase DNA synthesis

Purity
> 98% (HPLC)

Application
Phosphoramidite DNA synthesis, oligonucleotide synthesis

Ingredients
5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine

Storage
Store at -20C, dry and protected from light

Product Type
Nucleoside derivative

Usage
As a building block for automated DNA synthesis

Molecular Weight
722.80 g/mol

Shelf Life
2 years

Physical Form
Powder

Grade
Molecular Biology Grade

Appearance
White to off-white powder

CAS No
118619-50-2

HS Code
29349900

Solubility
Soluble in DMF, DMSO, and slightly soluble in water

Structural Formula
Refer to product image or chemical structure diagram

Ph Level
Neutral (in solution)

Shape
Crystalline powder

Spectral Data
H-NMR, C-NMR and mass spectra available on request

Stability
Stable under recommended storage

Sensitivity
Sensitive to moisture and light

Hazard Statements
Not classified as hazardous

Manufacturing Method
Synthetic, chemical modification of 2'-deoxyguanosine

Quality Control
Each batch tested by HPLC and MS

Transportation
Non-hazardous; no special transportation required

IUPAC Name
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-dimethylaminomethylene guanosine

Chemical Family
Nucleoside analog

Synonyms
DMT-dG(N-dma)-OH

Packaging
Supplied in amber glass vials, 100 mg, 250 mg, 1 g sizes

5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine Trade Information

Supply Ability
100 Per Week

Delivery Time
1 Week

Main Export Market(s)
South America, Australia, North America, Eastern Europe, Western Europe, Middle East, Africa, Central America, Asia

Main Domestic Market
All India

About 5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine

CAS No : [40094-22-2]

M.Wt. 824.90

M.F. C43H53N8O7P

Specification :

*Appearance: White to Off White Powder

*Purity by HPLC (%Area): NLT 98.0%

*1H NMR (Solvent:DMSO d6): Conforms with structure

*LCMS: Corresponds to Mass

*Moisture Content (KF w/w): NMT 1.0%

*Residual Solvents (%w/w): NMT 3.0%

*APHA in 0.2M DMSO solution: NMT 300

*Solubility: 0.2M in DMF

Advanced Protecting Group for DNA Synthesis

5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine is commonly used for introducing specific modifications at the guanosine site in oligonucleotide synthesis. Its DMT protective group and N2-dimethylaminomethylene modification facilitate selective incorporation during automated DNA synthesis, ensuring efficient coupling and high-yield results.

Stringent Quality Assurance

Each batch undergoes rigorous HPLC and mass spectrometric analysis to confirm purity (>98%) and chemical identity. All spectral data, including H-NMR and C-NMR, are available upon request. Its proven reliability makes it ideal for demanding research and molecular biology applications.

Safe, Stable, and Convenient Handling

This compound is classified as non-hazardous, making handling and international transportation straightforward. To preserve its stability and integrity, it is supplied in amber glass vials and should be stored at -20C, protected from moisture and light.

FAQ's of 5'-O-(4,4'-dimethoxytrityl)- N2-dimethylaminomethylene-2'-deoxy-guanosine:

Q: How should 5-O-(4,4-dimethoxytrityl)-N2-dimethylaminomethylene-2-deoxyguanosine be stored?

A: Store this compound at -20C in a dry place, protected from light and moisture to maintain optimal stability and shelf life.

Q: What is the primary application of this product in molecular biology?

A: It serves as a protected nucleoside analog for use in solid phase DNA synthesis, acting as a critical building block during automated oligonucleotide assembly.

Q: When should researchers request spectral data for this compound?

A: Researchers can request H-NMR, C-NMR, and mass spectra if additional verification or quality assurance documentation is required for their experiments.

Q: Where can this product be sourced or supplied?

A: This product is available in India through distributors, exporters, importers, manufacturers, retailers, suppliers, traders, and wholesalers.

Q: What process is used to manufacture this nucleoside analog?

A: The compound is synthesized via chemical modification of 2-deoxyguanosine, ensuring high purity and suitability for sensitive DNA synthesis protocols.

Q: How does this compound benefit automated oligonucleotide synthesis?

A: The DMT protective group and N2-dimethylaminomethylene modification enhance coupling efficiency, selectivity, and the overall yield of DNA assembly reactions.